![]() ![]() I’ll still be sure to prepare my Lapras plush for the manmade horrors of this mortal coil through every possible means. ![]() “Lapras, you’re too pure for this world.” The Pokémon Company/Bandai It’s unclear whether this plush is buoyant or even water-resistant, but we’d advise that you keep it confined to your living room or bedroom. I’d frankly be honored to have a Lapras dock upon our shores and venture out into the human world, which can often be an unwelcoming hellscape, a place riddled with inexplicable coldness and unwavering terror.īut Lapras was always a highly accommodating member of Ash Ketchum’s Pokémon party, letting the lackluster trainer jump on for a ride across the Orange Islands’ waters. which makes this big guy especially special. It should be said that Lapras is a water-type Pokémon, and it tends to stay away from land. Pokémon Center, by the way.) Pre-orders are open from Bandai’s Japanese storefront now, with shipments expect to be delivered beginning in July. (That’s more than 10 inches bigger than the $250 Lapras plush available from the U.S. And this one is for more than just for hugging: It’s perfect to sit on, and for imagining that it can carry us far, far away from our troubles.įor 79,400 Yen - or around $750 - this 47-inch Lapras can reside in your home. Inspired by the Pokémon anime’s most adorable mode of transportation, the company is releasing a gigantic Lapras plush. Bandai, purveyor of such goods as that gigantic Kirby plush and that gigantic Snorlax plush, has done it again.
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And this is the curvature of spacetime," Kopeikin said. "When you take a particle which has mass and put it to spacetime, then the particle actually distorts the geometry of spacetime which becomes not flat. "It follows what space does, so if space curves, then light is going to curve," Speck said. (Video via European Southern Observatory) This is one of the major predictions of relativity: that matter curves spacetime and that we can see that curvature simply by observing how light gets to Earth. University of Missouri physicist Sergei Kopeikin says, "So light rays are not propagating already along straight lines they are propagating along curved lines." We can see that if light had to pass close to something massive on its way to Earth, it arrives at a weird angle. It's only when using very precise equipment, like the Hubble telescope, that it becomes obvious that isn't true. It travels in a completely straight line." (Video via NASA) We think of it as, if you've got light traveling, it travels like a laser. Usually we think of space as just being this empty thing. Up until Einstein came along, we had a way of thinking about what space was, what mass was. We asked two physicists to walk us through the concept.Īngela Speck, head of astronomy at the University of Missouri, says: "It's really about how light in space behaves. The most common is probably the grid dipping under a planet, star or galaxy. (Video via PBS, YouTube / MegaGreenLucas) That's not an easy concept to grasp, so scientists use all kinds of analogies to help explain it. One of Albert Einstein's most important insights is that empty space can be curved and what we call gravity is really just a consequence of those curves. Einstein's theory of general relativity: 100 years of bent spacetime. ![]() “We all recognize that there’s a need for a scalable service provider in the space that is establishing a brand that is trusted,” he adds. “I don’t think there’s the capital around to just go, OK, we’re going to spend potentially a couple hundred million dollars on a clinical trial pathway, and we’re going to go build a global clinic network at the same time,” says Nyquvest. Oregon Psilocybin Entrepreneurs Navigate Business Requirements “Scale their experience with insurance companies across multiple sites.” “They’re saying we’ve become experts at the process,” says Sabrin about Novamind. The more patients that the company has worked with, the more opportunities they’ve had to deal directly with insurance. He notes that this is an important feature for a business model that will likely make much of its money through commercial third-party payers. One of the benefits of Novamind could be their expertise in dealing with insurance companies tempered through experience, says Sabrin. “Delix Therapeutics and the good work out of David Olson’s Lab at UC Davis is a good example,” he says.Īnother threat to this strategy could be failing to get reimbursements from third-party payers. Potential challenges to that model could include psychedelic treatments not catching on with patients, the FDA failing to approve therapies which use these substances, or the development of non-hallucinogenic psychedelics that don’t require a clinician’s assistance to administer, explains Sabrin. “This is especially true as more psychedelic therapies become approved by the FDA and available to patients that need them,” he adds. Sabrin says he would not be surprised if Numinus continues to acquire additional locations from other startups. “Scale will be necessary to drive down per patient acquisition cost and drive revenue,” says Sabrin. Consolidation is expected, agrees Sam Sabrin, senior advisor to Tabula Rasa and JLS, which invests in companies developing psychedelic-assisted therapies. ![]() The acquisition perhaps represents a trend in consolidation in the psychedelic space that Nyquvest expects to see more of in the next year. “I think they’ve really stood out amongst a number of groups that have emerged in the space as really a group that was very aligned in terms of our ethos around accessibility, looking toward the future of being able to provide psychedelic assisted psychotherapy in a very trusted and high integrity, high quality way.” “I’ve always been an admirer of what they’ve put together in the U.S.,” says Nyquvest of Novamind. When the acquisition is complete, Nyquvest says Numinus will operate 13 clinics in two countries, creating a cross borders platform for psychedelic therapy and clinical research. He says Novamind will join Numinus’s existing partnerships, including a collaboration with MAPS. Novamind has provided clinical research sites for both MindMed and the Usona Institute, says Nyquvest. “They are the clinical sites for a host of different trials with LSD as well as psilocybin.” “They’ve gotten a lot of support from insurance providers, so a number of their ketamine protocols are actually covered under insurance,” Nyquvest tells Lucid News. He says that part of what attracted him to Novamind was its business model, which he says is both sound and scalable. “The combination of Novamind’s network of mental health care clinics and research sites in the U.S., and Numinus’s leadership in psychedelic-assisted psychotherapy in Canada creates a best-in-class company.”Īccording to Nyquvest, the acquisition has been in the planning for several months. “This transaction offers significant value for Novamind’s shareholders,” adds Yaron Conforti Novamind CEO and co-founder in the statement. “Our combined capabilities will deliver exceptional value for our clients, employees and shareholders.” “We expect this acquisition will significantly bolster our financial performance, growing Numinus’ annual revenue to more than five times our current levels, and driving meaningful margin improvement through identified operating efficiencies,” says Payton Nyquvest, Numinus founder and CEO in a press release. Numinus projects that it will lead other companies in the sector in 2022 with annual revenue of approximately CAD$10 million ($7.9 million U.S.) based on the trailing four quarters. The all-share transaction for the acquisition of Toronto-based Novamind is expected to be complete in June 2022. ![]() is set to acquire Novamind Inc., which operates a network of psychiatry clinics with a focus on psychedelics. Vancouver-based mental health care company Numinus Wellness Inc. The psychedelics industry is seeing the first signs of a much anticipated consolidation. X40 community members can, however, use the material and quality profiles provided by us to get very good results with little effort. The materials offered in the Ultimaker Marketplace are only for the Ultimaker printers with 2.85mm filament. ![]() The print profiles are optimised for Ultimaker 3D printers, but the softwre will.
![]() If you want something bad enough, you’ll stop at nothing to get it. No one goes through life without fear – but successful people have a deep belief in themselves that allows them to push forward, knowing that no matter what happens, they are strong enough to handle it.Ĭreating a powerful vision for your life will also crush your fear of failure. What are the upsides and downsides of each option? What do you gain from each option? What would it cost you? By fully evaluating possible consequences, you can better use fear before it uses you. Plus, mentors and mastermind groups can help you achieve your goals through the power of proximity alone, encouraging you to take risks and helping you bounce back quickly from failures. And the more options you have, the more confident you’ll be. Even if you don’t take their advice directly – it may not be right for you – an alternative viewpoint can still inform your decision. ![]() This is another reason why it’s so important to find a mentor or join a mastermind group : They’ll understand where you’re coming from and where you want to go, so they can provide relevant solutions. It’s a good idea to get an outside perspective from someone who’s experienced a similar issue, like a colleague or friend. You may even have some options you’re not aware of. Write down ALL possible options, whether or not you like them. Write down all of your options, including those that initially may sound far-fetched. The first step toward making tough decisions is to get as specific as possible about what you want to get out of the process. If you don’t know the reasons you’re doing something, your brain will send you mixed signals and you won’t follow through. Remember, reasons come first answers will come second. Visualizing your goals “tricks” your brain into thinking that you’ve already achieved them. Successful people from entrepreneurs to athletes use goal visualization to help them achieve what they want – because it works. Without this clarity, making tough decisions becomes more difficult. Visualize your goals and make sure that whatever you choose to experience is aligned with your values and purpose. ![]() What’s the result you’re after? Why do you want to achieve it? You must be clear about your outcome(s) and its/their order of importance to you. ![]() Phase 1: OCC – Outcomes, Options, Consequences 1. But the best decision-makers also have a set of tools they can use to process big decisions and feel good about the choices they make. Those who set the intention of keeping a mindset of abundance and seeing life as happening for them instead of to them are always in a better position when faced with tough decisions in life – and dealing with the consequences – than those who do not. But there are plenty of people who know how to make a difficult decision – a decision that could shape everything from a company to a country. Or we become overwhelmed and have no idea where to start. Is it any wonder some of us have trouble making tough decisions ? We become paralyzed, worried that if we make the wrong decision terrible things will happen. “It is in your moments of decisions that your destiny is shaped.” One of Tony’s most powerful statements sums up the importance of decision-making like no one else can: How you ultimately make tough decisions can mean the difference between failure and success, as well as the difference between fulfillment and a pervasive sense of emptiness. ![]() ![]() But most solutions provided incomplete or inaccurate data, some times nothing at all. Suggestions like using Racerender o Dashware came up. In these two threads we discussed means of extracting the data: This was possible thanks to: I have not tested it with many cameras, so let me know if anything needs to be fixed. Otherwise, let me know.ĮDIT 2: You can contribute to this tool here: ĮDIT 3: Since many people want to use the data with other software, the GPMD2CSV tool now exports to GPX, KML and JSON formats too. If you wan to contribute to the new code base (javascript), you can do it here ĮDIT: The rest of this post discusses how to manually retrieve the data and can bus useful for customising and improving the results, but here's a package that lets Windows users extract the sensor data to spreadsheet format (csv) by just dropping the video files on the GPMD2CSV.bat file: It should work well with both H5 cameras on all resolutions and framerates. Gauges are also limited to H5 Black files recorded with the GPS on, but the fact is that the sensors record data even when the GPS is off, even in the H5 Session.ĮDIT 2019: The rest of this post is useful for geeks, but if you just want to convert your data, you can use the new telemetry extraction tool: While the Quick software can display some of the data in the "gauges" format, Hero5's video files have much more to it, many more sensors and detailed data: This information might be outdated and most links are broken. Note: This post was originally published in. A lot of tracks feature some buildings, fences, various rocks, obstacles and ditches and feel very well realized, realistic and at the end of the day fun. My favorite stage is probably in Kenya, where there are huge bumps into corners and then the track opens to a wide flat road and ends up in some easier corners. The thing i really like about the game are the stages itself, they are very varied, from very tight, punishing twisty turns, to wide gravel tracks where drifting is super enjoyable and forgiving. The game runs nice, at around 90-100 fps on my medium-end PC. Honestly it made me not regret purchasing my budget wheel all those years ago. ![]() Out of all the games I tried it played best with my wheel out of the box. A really As a casual racing games fan I really enjoy this game. This WRC 10 is therefore the penultimate opus of the French studio which will still have had the merit of bringing the series out of the mediocrity in which it stagnated, during the time when Milestone was in charge (the Metacritic ratings are from 80% on average during the Evolution Studios era to 60% during the Milestone era)Īs a casual racing games fan I really enjoy this game. Do not forget either that the license will change creamery in 2023, from KT Racing / Nacon to Codemasters / EA. Unfortunately, we feel that COVID has had its work, whether it is the proposed rallies that are no longer really in line with the 2021 calendar, more technical aspects of the game that have not changed a bit. Undoubtedly the most striking feature is of course the arrival of the choice of tire allocation for the rally, which adds a good layer of strategy in certain events including the Monte-Carlo. The stable manager mode is also welcome, although it is still not understood why you have to end the previously mentioned mode in order to be able to access it. The 50th anniversary mode finally allows you to take advantage of the discipline's old glories, and while we would have liked it to have been more fleshed out, it still makes an act of presence. This mode allows you to carry over the damage inflicted on the vehicle to the next stage, to place one or more service parks (and to impose a mandatory passage to a service park in order to equip the car with appropriate tyres when the road surface changes between two stages), and finally, the stages are played in one shot and cannot be replayed.WRC 10 is not a bad installment in the series, with its fair share of welcome novelties. ![]() In “Club” Mode, which allows players to create their own online events and championships, a realistic mode is now available to add an extra layer of difficulty. Rally Mexico in 2016 with Jari-Matti Latvala and Miikka Anttila in their Volkswagen Polo R WRC.The Safari Rally in Kenya in 2000 Richard Burns and Robert Reid in their Subaru Impreza S5 WRC ’99,.Rally Germany in 2002 with Sébastien Loeb and Daniel Elena in their Citroen Xsara WRC,. ![]() ![]() Rally Argentina in 2004 with Carlos Sainz and Marc Martí in their Citroen Xsara WRC,.Rally Argentina in 1994 with Didier Auriol and Bernard Occelli in their Toyota Celica Turbo 4WD,.After the 3 historical events added in October, five new events are now available in WRC 10! Famous driver and co-driver duos will compete in their cars of the time: Returning to the official WRC calendar in 2021 after a 7-year absence, it was won by Kalle Rovanperä for his 2nd victory of the season! Already present in WRC 10 since the launch through a historical event, the update brings 3 special stages in 2021 version to the experience and also joins the game’s Career mode.Īs an anniversary edition of the championship, WRC 10 already offers a large number of historical and key events of the championship since 1973. With winding and dusty mountain roads, sometimes on cliff sides, the Greek Rally is known to be particularly challenging for drivers. This new free update adds one of the most iconic rallies in WRC: the Acropolis Rally. The Acropolis Rally: an icon of the Championship returns. There were two versions available, the RS and GSR. The engine and transaxle were rotated 180° to better balance the weight and eliminate torque steer. The Lancer platform was redesigned in 1996, and along with it, the Evolution. The subsequent Evolution Lancer models all featured rear mechanical plate type LSD's. The GSR version of the Evolution I was the only Evolution Lancer released with a viscous limited-slip rear differential ( VLSD). 5,000 of the first generation Evolutions were sold between 19. The GSR came with all of the conveniences of a typical street car, including a digital screen climate control system. ![]() The RS version was released with a mechanical plate type rear limited-slip differential (LSD). The RS was a stripped-down version that lacked power windows and seats, anti-lock brakes, a rear wiper, and had steel wheels to weigh approximately 70 kg (154 lb) less than the 1,238 kg (2,729 lb) GSR, ready for racing or tuning. This engine was also used in the Mitsubishi RVR with the Hyper Sports Gear trim package, and the Mitsubishi Chariot Resort Runner GT. The first Lancer Evolution used the 2.0 L turbocharged DOHC engine and AWD drivetrain from the original Galant VR-4 in a Lancer chassis, and was sold in GSR and RS models. ![]() The Evolution X was produced for almost 10 years until Mitsubishi retired the Lancer Evolution in April 2016. The tenth and final generation of the Lancer Evolution, the Evolution X, was launched in Japan in 2007, and overseas markets in 2008. Various special versions available in other markets, particularly the UK, have official power outputs up to 446 PS (328 kW 440 hp). Therefore, each subsequent version has unofficially evolved above the advertised power figures, with the Japanese-market Evolution IX reaching an alleged output of around 321 PS (236 kW 317 hp). However, sources say Mitsubishi had already been producing cars with more power but had been underrating the official power outputs in order to comply with the agreement. Mitsubishi decided to export the eighth generation Evolution to the United States in 2003 after witnessing the success Subaru had in that market the previous year with the Subaru Impreza WRX.Īll domestic market versions, until the release of the Evolution IX in 2005, were limited by a gentlemen's agreement between Japanese car manufacturers to advertise no more than 280 PS (206 kW 276 hp). The Evolution was originally intended only for Japanese markets, but demand on the "grey import" market led the Evolution series to be offered through Ralliart dealer networks in the United Kingdom and in various European markets from around 1998. All generations use two-litre intercooled turbo inline four-cylinder engines and all-wheel drive systems. There have been ten official versions to date, and the designation of each model is most commonly a Roman numeral. The Mitsubishi Lancer Evolution, popularly referred to as the ' Evo', is a sports sedan and rally car based on the Lancer that was manufactured by Japanese manufacturer Mitsubishi Motors from 1992 until 2016. ![]() Swindling requires a certain amount of investment. ![]() In order for people to give you money, you have to look like you already have it. The venture was going to be called, with characteristic modesty, the Anna Delvey Foundation, and she came really close to making it happen. But the con artist was arrested before she could complete a more ambitious project: securing $25 million (€22 million) from an investment fund to set up a private art club with branches in Hong Kong, Los Angeles, Dubai and Manhattan. The list of creditors includes hotels and a private airline. Julia Garner as Anna Delvey in 'Inventing Anna.’ ©Netflix/Courtesy Everett Collection / Cordon Pressĭelvey was sentenced to four to 12 years in prison for failing to pay bills worth $200,000. Many of these outfits have been carefully reproduced in the Netflix series. She hired a stylist, Anastasia Walker, to help her with her look at the hearings, and together the pair opened up an Instagram account to show them off called Anna Delvey Court Looks. Even during her trial she continued to promote herself tirelessly. Audiences enjoy watching these supposedly sophisticated people getting duped, and they are also taken in by Delvey’s own complete lack of self-judgment and unlimited capacity for lying. Her story will soon be told by HBO with actress Anne Hathaway in the lead role.ĭelvey’s con game seems almost modest by comparison, but her story is beguiling because of where it took place, among Manhattan’s elite. Elizabeth Holmes, the founder of Theranos (there are two projects in the works about her, added to an existing docuseries and podcasts) extracted a lot more money from investors with her unicorn company specializing in blood analysis that was full of hot air, and Rebekah Neumann lost as much as $100 million (€88 million) a week at WeWork, the company she co-founded with her husband Adam Neumann. In financial terms, Delvey may well be the least ambitious of all the millenial swindlers who emerged in the last decade, and whose stories are now flooding commercial fiction. Delvey spent around $200,000 (€176,000) to repay her debts and the rest to pay her legal fees. That’s because Netflix paid her $320,000 (€282,000) for her life rights to the series. I’m not sorry.” And when a BBC reporter asked her whether crime pays, she replied yes, literally. At the end of her trial, she told a reporter for The New York Times: “The thing is. Shonda Rhimes: ‘I see myself not as one of TV’s most powerful women but as one of TV’s most powerful people’Īlthough the series is not 100% true to reality, this dialogue sounds a lot like the real ones that Delvey has had with journalists in the past. ![]() The abundance and widespread distribution of transposable elements required a unified classification to divide these sequences into different lineages though it is still a subject of debate 11– 13. Transposable elements comprised a considerable proportion of eukaryotic and prokaryotic genome 9, e.g., approximately 3–20% of the genomes in many filamentous fungi 10, 10%, 12%, 37%, 45% and 80% of the genome in fish, Caenorhabditis elegans, mouse, human and some plants, respectively 2, 3. ![]() Although the recent advancements to the understanding of TE evolution, there are still considerable gaps of knowledge to completely understand the evolutionary interplay between host and genomic parasites 8, 9. The complexity and paraphyletic origin of TEs poses substantial challenges to the scientific community, including the detection, classification, assembly, annotations and mapping of genomic variants 8. The influence of TEs on genome organization and evolution is not surprising and enough information is available about impact of TEs in the host genome evolution. ![]() Moreover, TEs have the ability to modify the expression of their host genes by juxtaposing new cis-regulatory sequences, and can also be co-opted to new host function and give rise to new host genes 3– 6, through a phenomenon known as molecular domestication 7. ![]() During transposition, they may disrupt coding or regulatory sequences, and the high similar copies, which dispersed in the genome, can serve as source of non-homologous recombination breaking points resulting in chromosomal rearrangement such as inversion, deletion, translocation, and duplication. However, very small proportion of TE sequences are currently active with intact open reading frame (ORF) for transposase and most have many deletions and substitution due to vertical inactivation events by the host, and hence they are the inactive remains of once active copies 4. Transposable elements have considerable influence on the evolution of host genome due to their propagation and replication within host genome 3. Once these elements exploit the host cellular machinery for their own replication, they may have a large negative impact on the host fitness 1– 3. Transposable elements (TEs) are DNA sequences (usually less than 15 kb), which have the ability to jump and change its location within the genome, also known as genomic parasites 1, 2. Our present report revealed the diversity and distribution of MLEs in Rhus gall aphid genomes and expanded our understandings on the characterization of transposable elements in aphid genomes, which might be useful as genetic markers and tools and would play an important role in genomic evolution and adaptation of aphids. Phylogenetic analysis showed that all the 121 MLE sequences belonged to four subfamilies, i.e., Mauritiana, Drosophila, Vertumana and Irritans, among which Drosophila and Vertumana subfamilies were reported in aphids for the first time. The sequences of MLEs ranged from 1 to 1.4 kb in length and the structural analysis of the MLEs showed that only five copies were potentially active with intact open reading frame (ORF) and terminal inverted repeats ( TIRs). In total, 121 MLEs were detected in the genomes of the seven investigated species of Rhus gall aphids, which showed a wide distribution in both close and distant related species. Mariner like elements (MLEs) were searched in the genomes of seven species of Rhus gall aphids belonging to six genera. Mariner/DD34D family belongs to class II transposable elements which is widely spread in the genomes of insects and have considerable role in genomic evolution. Transposable elements (TEs), also known as jumping genes, are widely spread in the genomes of insects and play a considerable role in genomic evolution. |